The increase in non - crossbridge forces after stretch of activated striated muscle 2 is related to titin
نویسندگان
چکیده
1 The increase in non-crossbridge forces after stretch of activated striated muscle 2 is related to titin isoforms 3 4 5 6 Anabelle S. Cornachione * 7 Felipe Leite * 8 Maria Angela Bagni 9 Dilson E. Rassier # 10 11 12 13 14 15 # Corresponding author: 475 Pine Avenue W., Montreal (QC), Canada, H2W 1S4 16 email: [email protected] 17 18 * authors contributed equally to the work 19 20 Article re-submitted to the American Journal of Physiology 21 22 August 2015 23 Articles in PresS. Am J Physiol Cell Physiol (September 24, 2015). doi:10.1152/ajpcell.00156.2015
منابع مشابه
The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms.
Skeletal muscles present a non-cross-bridge increase in sarcomere stiffness and tension on Ca(2+) activation, referred to as static stiffness and static tension, respectively. It has been hypothesized that this increase in tension is caused by Ca(2+)-dependent changes in the properties of titin molecules. To verify this hypothesis, we investigated the static tension in muscles containing differ...
متن کاملRegulation of muscle force in the absence of actin-myosin-based cross-bridge interaction
Leonard TR, Herzog W. Regulation of muscle force in the absence of actin-myosin-based cross-bridge interaction. Am J Physiol Cell Physiol 299: C14–C20, 2010. First published March 31, 2010; doi:10.1152/ajpcell.00049.2010.—For the past half century, the sliding filament-based cross-bridge theory has been the cornerstone of our understanding of how muscles contract. According to this theory, acti...
متن کاملSarcomere mechanics in striated muscles: from molecules to sarcomeres to cells.
Muscle contraction is commonly associated with the cross-bridge and sliding filament theories, which have received strong support from experiments conducted over the years in different laboratories. However, there are studies that cannot be readily explained by the theories, showing 1) a plateau of the force-length relation extended beyond optimal filament overlap, and forces produced at long s...
متن کاملTowards a molecular understanding of the elasticity of titin.
Vertebrate striated muscle behaves elastically when stretched and this property is thought to reside primarily within the giant filamentous protein, titin (connectin). The elastic portion of titin comprises two distinct structural motifs, immunoglobulin (Ig) domains and the PEVK titin, which is a novel motif family rich in proline, glutamate, valine and lysine residues. The respective contribut...
متن کاملNon-crossbridge stiffness in active muscle fibres.
Stretching of an activated skeletal muscle induces a transient tension increase followed by a period during which the tension remains elevated well above the isometric level at an almost constant value. This excess of tension in response to stretching has been called 'static tension' and attributed to an increase in fibre stiffness above the resting value, named 'static stiffness'. This observa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015